Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: forodesine, ulodesine, forodesine hydrochloride | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 43 Parkinson's papers of 7,441 | 0.50 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8877
Sealed predictions
- PNP in dopamine neurons, braak+0.02 (p 0.964) → +0.19 (p 0.623)receipt 8885
Swarm cases
receipt 8885: PNP in dopamine neurons, braak
- power
- full sample +0.08 (p 0.754, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.728, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.962, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.19, sign flips 3; without severely affected donors +0.08 (p 0.754, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PNP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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