parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in renal collecting duct intercalated cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	9 Parkinson's papers of 411	0.70
pathways Reactome	15 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 6760

receipt 6768: PLCG2 in dopamine neurons, braak

power: full sample -0.25 (p 0.319, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.23 (p 0.355, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.269, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.18, sign flips 0; without severely affected donors -0.25 (p 0.319, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLCG2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6767: PLCG2 in microglia, braak

power: full sample +0.16 (p 0.526, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.15 (p 0.549, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.15 (p 0.549, n 18). could be the mix.
skeptic: leave-one-out range +0.04 to +0.27, sign flips 0; without severely affected donors +0.16 (p 0.526, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLCG2 in microglia.

case closed: nothing better to follow up.

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