Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (12 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 211 Parkinson's papers of 453 | 0.29 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3772
Sealed predictions
- PITX3 in dopamine neurons, braak-0.79 (p 0.011) → +0.00 (p 1.000)receipt 3780
Swarm cases
receipt 3780: PITX3 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.105, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.044, n 18). not the mix.
- skeptic
- leave-one-out range -0.57 to -0.33, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PITX3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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