Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: sgi-1776, lgh-447, azd-1208 | 0.80 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 1,995 | 0.85 |
| pathways Reactome | 4 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 1120
Sealed predictions
- PIM1 in dopamine neurons, braak-0.45 (p 0.224) → -0.39 (p 0.297)receipt 1127
Swarm cases
receipt 1127: PIM1 in dopamine neurons, braak
- power
- full sample -0.34 (p 0.167, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.369, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.188, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.167, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PIM1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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