Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PIK3R2

phosphoinositide-3-kinase regulatory subunit 2

translation score 0.61, read 2026-10-17; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.35 from other evidence0.00
cell type
Human Protein Atlas		group enriched, including oligodendrocyte progenitor cells; strongest in ependymal cells0.75
chemistry
Open Targets		compounds already reach it: pilaralisib, pictilisib, omipalisib +210.90
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 3100.85
pathways
Reactome		48 pathways; mostly immune signalling0.90
proposal for PIK3R2, translation score 0.61

Knock down and overexpress PIK3R2 in oligodendrocytes; measure IL-1β and TNF release and surface HLA-DR and α-synuclein uptake and myelin basic protein output under oxidative stress.

Cell type
oligodendrocytes
Direction
Both arms: public data does not say which way helps; existing compounds already reach the inhibition arm.
Molecular readout
IL-1β and TNF release and surface HLA-DR
Functional readout
α-synuclein uptake and myelin basic protein output under oxidative stress
Rule-out
If neither arm moves IL-1β by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of PIK3R2 in iPSC-derived oligodendrocytes; n = 3 differentiations; readouts: IL-1β and TNF release and surface HLA-DR; α-synuclein uptake and myelin basic protein output under oxidative stress. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. PIK3R2 in dopamine neurons, braakn/a → n/areceipt 0877
  2. PIK3R2 in oligodendrocytes, braakn/a → n/areceipt 0876

Swarm cases

receipt 0877: PIK3R2 in dopamine neurons, braak

cell type
PIK3R2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PIK3R2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0876: PIK3R2 in oligodendrocytes, braak

cell type
PIK3R2 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PIK3R2 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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