Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in neutrophils | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 24 Parkinson's papers of 444 | 0.58 |
| pathways Reactome | 4 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 3965
Sealed predictions
- PICALM in microglia, braak-0.04 (p 0.927) → -0.21 (p 0.583)receipt 3971
- PICALM in dopamine neurons, braak+0.12 (p 0.767) → -0.27 (p 0.489)receipt 3972
Swarm cases
receipt 3972: PICALM in dopamine neurons, braak
- power
- full sample -0.03 (p 0.915, n 18), 95% CI -0.49 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.908, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.403, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.08, sign flips 5; without severely affected donors -0.03 (p 0.915, n 18). fragile.
- cell type
- strongest in OPCs: +0.62 (p 0.0057, n 18) vs -0.03 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PICALM in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PICALM · OPCs · braak: substantia nigra, an independent cohort (already registered)
receipt 3971: PICALM in microglia, braak
- power
- full sample -0.11 (p 0.658, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.603, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.05 (p 0.834, n 18). could be the mix.
- skeptic
- leave-one-out range -0.25 to -0.00, sign flips 0; without severely affected donors -0.11 (p 0.658, n 18). fragile.
- cell type
- strongest in OPCs: +0.62 (p 0.0057, n 18) vs -0.11 in microglia. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PICALM in microglia.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PICALM · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.63 p 0.026 (needs p < 5.0e-4)
Receipts
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