parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in rod photoreceptor cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 21	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 9424

PHYHD1 in dopamine neurons, braak-0.29 (p 0.457) → -0.30 (p 0.430)receipt 9431
PHYHD1 in astrocytes, braak+0.22 (p 0.567) → +0.45 (p 0.230)receipt 9430

receipt 9431: PHYHD1 in dopamine neurons, braak

power: full sample -0.37 (p 0.135, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.265, n 18). could be the mix.
skeptic: leave-one-out range -0.53 to -0.27, sign flips 0; without severely affected donors -0.37 (p 0.135, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PHYHD1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9430: PHYHD1 in astrocytes, braak

power: full sample +0.33 (p 0.188, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.38 (p 0.116, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.38 (p 0.123, n 18). could be the mix.
skeptic: leave-one-out range +0.22 to +0.47, sign flips 0; without severely affected donors +0.33 (p 0.188, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PHYHD1 in astrocytes.

case closed: nothing better to follow up.

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