Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: mifepristone, ulipristal acetate, trimegestone +28 | 1.00 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 7 Parkinson's papers of 4,879 | 0.73 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 9451
Sealed predictions
- PGR in dopamine neurons, braak+0.61 (p 0.078) → +0.29 (p 0.457)receipt 9457
Swarm cases
receipt 9457: PGR in dopamine neurons, braak
- power
- full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.460, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.398, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.36, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PGR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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