Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 1 stopped | 0.20 |
| literature PubMed | 33 Parkinson's papers of 1,503 | 0.54 |
| pathways Reactome | 4 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 3711
Sealed predictions
- PGK1 in dopamine neurons, braak+0.47 (p 0.206) → +0.30 (p 0.426)receipt 3719
Swarm cases
receipt 3719: PGK1 in dopamine neurons, braak
- power
- full sample +0.23 (p 0.369, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.258, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.258, n 18). could be the mix.
- skeptic
- leave-one-out range +0.13 to +0.41, sign flips 0; without severely affected donors +0.23 (p 0.369, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PGK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts