Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in leydig cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 24 Parkinson's papers of 542 | 0.58 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4026
Sealed predictions
- PENK in dopamine neurons, braak-0.11 (p 0.787) → +0.26 (p 0.493)receipt 4032
Swarm cases
receipt 4032: PENK in dopamine neurons, braak
- power
- full sample +0.12 (p 0.633, n 18), 95% CI -0.37 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.12 (p 0.646, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.509, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.28, sign flips 1; without severely affected donors +0.12 (p 0.633, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PENK in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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