Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 74 Parkinson's trials, 3 stopped | 0.95 |
| literature PubMed | 132 Parkinson's papers of 212 | 0.36 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11219
Sealed predictions
- PDSS2 in dopamine neurons, braak+0.29 (p 0.456) → -0.04 (p 0.925)receipt 11226
Swarm cases
receipt 11226: PDSS2 in dopamine neurons, braak
- power
- full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.25 (p 0.323, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.323, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.25, sign flips 1; without severely affected donors +0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDSS2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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