Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: sodium dichloroacetate | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 1,297 | 0.74 |
| pathways Reactome | 3 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 9389
Sealed predictions
- PDK4 in dopamine neurons, braak-0.46 (p 0.209) → -0.62 (p 0.073)receipt 9395
Swarm cases
receipt 9395: PDK4 in dopamine neurons, braak
- power
- full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.114, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.33, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDK4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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