Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PDHA2

pyruvate dehydrogenase E1 subunit alpha 2

translation score 0.39, read 2026-10-18; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.17 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (late primary spermatocytes)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
3 pathways; mostly energy0.60

No case: the score is under the bar. Receipt 2123

Sealed predictions

  1. PDHA2 in dopamine neurons, braakn/a → n/areceipt 2132

Swarm cases

receipt 2132: PDHA2 in dopamine neurons, braak

cell type
PDHA2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDHA2 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts