Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (cone photoreceptor cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: pentoxifylline, dipyridamole | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 62 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3308
Sealed predictions
- PDE6H in dopamine neurons, braak-0.18 (p 0.646) → +0.75 (p 0.019)receipt 3316
Swarm cases
receipt 3316: PDE6H in dopamine neurons, braak
- power
- full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.754, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.754, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDE6H in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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