Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in müller glia | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10394
Sealed predictions
- PCSK2 in dopamine neurons, braak+0.10 (p 0.790) → +0.25 (p 0.517)receipt 10403
Swarm cases
receipt 10403: PCSK2 in dopamine neurons, braak
- power
- full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.31, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCSK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts