Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including other brain neurons; strongest in neuroendocrine cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 351 | 0.91 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10254
Sealed predictions
- PCSK1 in dopamine neurons, braak+0.56 (p 0.114) → +0.18 (p 0.646)receipt 10262
Swarm cases
receipt 10262: PCSK1 in dopamine neurons, braak
- power
- full sample +0.36 (p 0.142, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.156, n 18). could be the mix.
- skeptic
- leave-one-out range +0.28 to +0.49, sign flips 0; without severely affected donors +0.36 (p 0.142, n 18). fragile.
- cell type
- strongest in OPCs: -0.61 (p 0.0075, n 18) vs +0.36 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCSK1 in dopamine neurons.
case closed: every proposal failed a challenge.
Receipts
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