Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain excitatory neurons (953 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 12240
Sealed predictions
- PCLO in dopamine neurons, braak+0.64 (p 0.063) → -0.06 (p 0.870)receipt 12247
Swarm cases
receipt 12247: PCLO in dopamine neurons, braak
- power
- full sample +0.35 (p 0.156, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.35 (p 0.150, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.221, n 18). could be the mix.
- skeptic
- leave-one-out range +0.30 to +0.54, sign flips 0; without severely affected donors +0.35 (p 0.156, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCLO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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