parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.28 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in podocytes	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 1405

receipt 1412: PBX2 in dopamine neurons, braak

power: full sample -0.55 (p 0.019, n 18), 95% CI -0.81 to -0.11. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.56 (p 0.016, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.71 (p 0.0010, n 18). not the mix.
skeptic: leave-one-out range -0.68 to -0.49, sign flips 0; without severely affected donors -0.55 (p 0.019, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PBX2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1411: PBX2 in microglia, braak

power: full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.15 (p 0.544, n 18). could be the mix.
skeptic: leave-one-out range -0.39 to -0.11, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PBX2 in microglia.

case closed: nothing better to follow up.

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