Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (14 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 12 Parkinson's papers of 2,285 | 0.66 |
| pathways Reactome | 2 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 7123
Sealed predictions
- PAX5 in dopamine neurons, braak-0.48 (p 0.195) → -0.04 (p 0.909)receipt 7130
Swarm cases
receipt 7130: PAX5 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.254, n 18), 95% CI -0.66 to +0.21. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.302, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.070, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.20, sign flips 0; without severely affected donors -0.28 (p 0.254, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PAX5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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