Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.02) | 0.04 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 313 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7587
Sealed predictions
- PARP12 in dopamine neurons, braak-0.75 (p 0.020) → -0.50 (p 0.168)receipt 7593
Swarm cases
receipt 7593: PARP12 in dopamine neurons, braak
- power
- full sample -0.63 (p 0.0051, n 18), 95% CI -0.85 to -0.23. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.56 (p 0.015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0080, n 18). not the mix.
- skeptic
- leave-one-out range -0.73 to -0.58, sign flips 0; without severely affected donors -0.63 (p 0.0051, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PARP12 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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