Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: talazoparib, 2x-121, amelparib dihydrochloride dihydrate +10 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 139 Parkinson's papers of 8,944 | 0.35 |
| pathways Reactome | 8 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 2478
Sealed predictions
- PARP1 in dopamine neurons, braak+0.36 (p 0.341) → +0.05 (p 0.893)receipt 2486
Swarm cases
receipt 2486: PARP1 in dopamine neurons, braak
- power
- full sample +0.08 (p 0.748, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.754, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.22, sign flips 2; without severely affected donors +0.08 (p 0.748, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PARP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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