parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in oocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	30 Parkinson's papers of 280	0.55
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 6262

receipt 6271: PARL in dopamine neurons, braak

power: full sample +0.05 (p 0.854, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.337, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.21, sign flips 4; without severely affected donors +0.05 (p 0.854, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PARL in dopamine neurons.

case closed: nothing better to follow up.

receipt 6270: PARL in microglia, braak

power: full sample +0.48 (p 0.046, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.45 (p 0.063, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.37 (p 0.132, n 18). could be the mix.
skeptic: leave-one-out range +0.41 to +0.65, sign flips 0; without severely affected donors +0.48 (p 0.046, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PARL in microglia.

case closed: nothing better to follow up.

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