Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: pf-03758309 | 0.80 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 570 | 0.74 |
| pathways Reactome | 11 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3718
Sealed predictions
- PAK4 in dopamine neurons, braak-0.23 (p 0.549) → -0.19 (p 0.631)receipt 3725
Swarm cases
receipt 3725: PAK4 in dopamine neurons, braak
- power
- full sample -0.25 (p 0.310, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.198, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.16, sign flips 0; without severely affected donors -0.25 (p 0.310, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PAK4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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