Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.21 (overall 0.13) | 0.21 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (b-cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2248
Sealed predictions
- P2RX5 in dopamine neurons, braak-0.27 (p 0.487) → -0.25 (p 0.514)receipt 2256
Swarm cases
receipt 2256: P2RX5 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.269, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.487, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.194, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.21, sign flips 0; without severely affected donors -0.28 (p 0.269, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for P2RX5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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