parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in rod photoreceptor cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 227	0.79
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6908

receipt 6917: OXR1 in dopamine neurons, braak

power: full sample +0.30 (p 0.228, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.145, n 18). could be the mix.
skeptic: leave-one-out range +0.22 to +0.46, sign flips 0; without severely affected donors +0.30 (p 0.228, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OXR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6916: OXR1 in microglia, braak

power: full sample +0.17 (p 0.509, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.26 (p 0.302, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.29 (p 0.246, n 18). could be the mix.
skeptic: leave-one-out range +0.06 to +0.29, sign flips 0; without severely affected donors +0.17 (p 0.509, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OXR1 in microglia.

case closed: nothing better to follow up.

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