Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.06 (overall 0.03) | 0.06 |
| cell type Human Protein Atlas | cell type enriched outside the brain (retinal ganglion cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6300
Sealed predictions
- OR4D9 in dopamine neurons, braak+0.21 (p 0.591) → +0.94 (p 2.1e-4)receipt 6308
Swarm cases
receipt 6308: OR4D9 in dopamine neurons, braak
- power
- full sample +0.63 (p 0.0054, n 18), 95% CI +0.23 to +0.85. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.56 (p 0.015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.57 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range +0.59 to +0.83, sign flips 0; without severely affected donors +0.63 (p 0.0054, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for OR4D9 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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