parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in endometrial ciliated cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 696	0.79
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 7842

receipt 7850: OMG in dopamine neurons, braak

power: full sample +0.29 (p 0.239, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.36 (p 0.142, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.130, n 18). could be the mix.
skeptic: leave-one-out range +0.20 to +0.44, sign flips 0; without severely affected donors +0.29 (p 0.239, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OMG in dopamine neurons.

case closed: nothing better to follow up.

receipt 7849: OMG in oligodendrocytes, braak

power: full sample +0.39 (p 0.109, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.41 (p 0.091, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.39 (p 0.111, n 18). could be the mix.
skeptic: leave-one-out range +0.31 to +0.54, sign flips 0; without severely affected donors +0.39 (p 0.109, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OMG in oligodendrocytes.

case closed: nothing better to follow up.

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