Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

NUP42

nucleoporin 42

translation score 0.75, read 2026-10-17; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		genetic association 0.56 (overall 0.34)0.56
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in early spermatids0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 130.91
pathways
Reactome		30 pathways; mostly protein handling0.90
proposal for NUP42, translation score 0.75

Knock down and overexpress NUP42 in oligodendrocytes; measure proteasome activity and the load of ubiquitinated protein and α-synuclein uptake and myelin basic protein output under oxidative stress.

Cell type
oligodendrocytes
Direction
Both arms: public data does not say which way helps.
Molecular readout
proteasome activity and the load of ubiquitinated protein
Functional readout
α-synuclein uptake and myelin basic protein output under oxidative stress
Rule-out
If neither arm moves proteasome activity by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of NUP42 in iPSC-derived oligodendrocytes; n = 3 differentiations; readouts: proteasome activity and the load of ubiquitinated protein; α-synuclein uptake and myelin basic protein output under oxidative stress. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. NUP42 in dopamine neurons, braakn/a → n/areceipt 0925
  2. NUP42 in oligodendrocytes, braakn/a → n/areceipt 0924

Swarm cases

receipt 0925: NUP42 in dopamine neurons, braak

cell type
NUP42 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NUP42 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0924: NUP42 in oligodendrocytes, braak

cell type
NUP42 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NUP42 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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