Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.03 (overall 0.08) | 0.03 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (hepatic stellate cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 42 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 206 | 0.79 |
| pathways Reactome | 9 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 3533
Sealed predictions
- NTF3 in dopamine neurons, braak-0.52 (p 0.149) → +0.00 (p 1.000)receipt 3541
Swarm cases
receipt 3541: NTF3 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.369, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.337, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.056, n 18). could be the mix.
- skeptic
- leave-one-out range -0.37 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.369, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NTF3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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