Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in lactotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 13 Parkinson's papers of 2,557 | 0.65 |
| pathways Reactome | 20 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 4647
Sealed predictions
- NRG1 in dopamine neurons, braak+0.58 (p 0.102) → +0.47 (p 0.197)receipt 4654
Swarm cases
receipt 4654: NRG1 in dopamine neurons, braak
- power
- full sample +0.62 (p 0.0060, n 18), 95% CI +0.22 to +0.84. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.68 (p 0.0017, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.69 (p 0.0014, n 18). not the mix.
- skeptic
- leave-one-out range +0.57 to +0.80, sign flips 0; without severely affected donors +0.62 (p 0.0060, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NRG1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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