Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 22 Parkinson's papers of 242 | 0.59 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2965
Sealed predictions
- NPTX2 in dopamine neurons, braak+0.00 (p 1.000) → -0.01 (p 0.982)receipt 2972
Swarm cases
receipt 2972: NPTX2 in dopamine neurons, braak
- power
- full sample -0.03 (p 0.894, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.09, sign flips 5; without severely affected donors -0.03 (p 0.894, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NPTX2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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