Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: setanaxib | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 36 Parkinson's papers of 4,565 | 0.53 |
| pathways Reactome | 3 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 2501
Sealed predictions
- NOX4 in dopamine neurons, braak+0.61 (p 0.078) → +0.65 (p 0.058)receipt 2508
Swarm cases
receipt 2508: NOX4 in dopamine neurons, braak
- power
- full sample +0.66 (p 0.0029, n 18), 95% CI +0.28 to +0.86. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.62 (p 0.0062, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.64 (p 0.0039, n 18). not the mix.
- skeptic
- leave-one-out range +0.62 to +0.75, sign flips 0; without severely affected donors +0.66 (p 0.0029, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NOX4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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