Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (enteric stem cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: setanaxib | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 25 Parkinson's papers of 2,157 | 0.57 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7108
Sealed predictions
- NOX1 in dopamine neurons, braak+0.04 (p 0.928) → +0.45 (p 0.219)receipt 7116
Swarm cases
receipt 7116: NOX1 in dopamine neurons, braak
- power
- full sample +0.17 (p 0.493, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.17 (p 0.509, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.24, sign flips 0; without severely affected donors +0.17 (p 0.493, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NOX1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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