Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 70 | 0.76 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7314
Sealed predictions
- NMD3 in dopamine neurons, braak-0.11 (p 0.787) → +0.88 (p 0.002)receipt 7321
Swarm cases
receipt 7321: NMD3 in dopamine neurons, braak
- power
- full sample +0.46 (p 0.056, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.46 (p 0.054, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.029, n 18). not the mix.
- skeptic
- leave-one-out range +0.39 to +0.64, sign flips 0; without severely affected donors +0.46 (p 0.056, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NMD3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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