Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

NKX2-1

NK2 homeobox 1

translation score 0.25, read 2026-10-23; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.02 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (transitional alveolar cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
10 Parkinson's papers of 1,1620.69
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 7978

Sealed predictions

  1. NKX2-1 in dopamine neurons, braakn/a → n/areceipt 7985

Swarm cases

receipt 7985: NKX2-1 in dopamine neurons, braak

cell type
NKX2-1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NKX2-1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts