Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

NICN1

nicolin 1, tubulin polyglutamylase complex subunit

translation score 0.45, read 2026-10-17; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.30 from other evidence0.00
cell type
Human Protein Atlas
group enriched, including brain inhibitory neurons; strongest in bergmann glia0.75
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 1243

Sealed predictions

  1. NICN1 in dopamine neurons, braakn/a → n/areceipt 1250

Swarm cases

receipt 1250: NICN1 in dopamine neurons, braak

cell type
NICN1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NICN1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts