Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 48 Parkinson's papers of 1,734 | 0.49 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 3117
Sealed predictions
- NEDD4 in dopamine neurons, braak+0.52 (p 0.150) → +0.79 (p 0.011)receipt 3124
Swarm cases
receipt 3124: NEDD4 in dopamine neurons, braak
- power
- full sample +0.67 (p 0.0024, n 18), 95% CI +0.29 to +0.87. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.70 (p 0.0013, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.71 (p 9.1e-4, n 18). not the mix.
- skeptic
- leave-one-out range +0.62 to +0.78, sign flips 0; without severely affected donors +0.67 (p 0.0024, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NEDD4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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