Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.40 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (late primary spermatocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: metformin hydrochloride, metformin, me-344 | 1.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 30 | 0.91 |
| pathways Reactome | 2 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 0642
Sealed predictions
- NDUFA7 in dopamine neurons, braak-0.04 (p 0.909) → -0.52 (p 0.151)receipt 0648
Swarm cases
receipt 0648: NDUFA7 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.393, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.509, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NDUFA7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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