parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in granulosa cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 1,888	0.76
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 10106

receipt 10114: NDP in dopamine neurons, braak

power: full sample -0.13 (p 0.615, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.28 to -0.06, sign flips 0; without severely affected donors -0.13 (p 0.615, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NDP in dopamine neurons.

case closed: nothing better to follow up.

receipt 10113: NDP in astrocytes, braak

power: full sample +0.05 (p 0.834, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.05 (p 0.834, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.16, sign flips 4; without severely affected donors +0.05 (p 0.834, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NDP in astrocytes.

case closed: nothing better to follow up.

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