parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in distal convoluted tubule cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 629	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6557

receipt 6566: NAIP in dopamine neurons, braak

power: full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.976, n 18). could be the mix.
skeptic: leave-one-out range -0.18 to +0.04, sign flips 3; without severely affected donors -0.07 (p 0.794, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAIP in dopamine neurons.

case closed: nothing better to follow up.

receipt 6565: NAIP in microglia, braak

power: full sample -0.26 (p 0.289, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.25 (p 0.315, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.289, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAIP in microglia.

case closed: nothing better to follow up.

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