Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

MTNR1A

melatonin receptor 1A

translation score 0.41, read 2026-10-18; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.24 from other evidence0.00
cell type
Human Protein Atlas
not detected in single-cell data0.00
chemistry
Open Targets
compounds already reach it: melatonin, agomelatine, piromelatine +21.00
trials
ClinicalTrials.gov
16 Parkinson's trials, 3 stopped0.85
literature
PubMed
2 Parkinson's papers of 2380.85
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 1811

Sealed predictions

  1. MTNR1A in dopamine neurons, braakn/a → n/areceipt 1819

Swarm cases

receipt 1819: MTNR1A in dopamine neurons, braak

cell type
MTNR1A is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MTNR1A in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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