parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in kupffer cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 502	0.79
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 8307

receipt 8315: MSR1 in dopamine neurons, braak

power: full sample +0.38 (p 0.120, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.38 (p 0.120, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.107, n 18). could be the mix.
skeptic: leave-one-out range +0.29 to +0.58, sign flips 0; without severely affected donors +0.38 (p 0.120, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MSR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8314: MSR1 in microglia, braak

power: full sample +0.34 (p 0.161, n 18), 95% CI -0.15 to +0.70. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.34 (p 0.161, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.31 (p 0.211, n 18). could be the mix.
skeptic: leave-one-out range +0.26 to +0.47, sign flips 0; without severely affected donors +0.34 (p 0.161, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MSR1 in microglia.

case closed: nothing better to follow up.

loading the receipts