Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophil progenitors) | 0.10 |
| chemistry Open Targets | compounds already reach it: rebimastat, cts-1027, doxycycline hyclate +1 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 5 Parkinson's papers of 2,750 | 0.76 |
| pathways Reactome | 4 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3234
Sealed predictions
- MMP8 in dopamine neurons, braak+0.32 (p 0.407) → +0.25 (p 0.508)receipt 3241
Swarm cases
receipt 3241: MMP8 in dopamine neurons, braak
- power
- full sample +0.31 (p 0.204, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range +0.24 to +0.48, sign flips 0; without severely affected donors +0.31 (p 0.204, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MMP8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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