Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (endometrial secretory cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: marimastat, doxycycline hyclate, doxycycline +1 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 13 Parkinson's papers of 10,715 | 0.65 |
| pathways Reactome | 6 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3171
Sealed predictions
- MMP1 in dopamine neurons, braak+0.32 (p 0.407) → +0.63 (p 0.068)receipt 3177
Swarm cases
receipt 3177: MMP1 in dopamine neurons, braak
- power
- full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.285, n 18). could be the mix.
- skeptic
- leave-one-out range +0.26 to +0.50, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MMP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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