Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 1132
Sealed predictions
- MINK1 in dopamine neurons, braak-0.75 (p 0.021) → -0.27 (p 0.487)receipt 1138
Swarm cases
receipt 1138: MINK1 in dopamine neurons, braak
- power
- full sample -0.55 (p 0.017, n 18), 95% CI -0.81 to -0.12. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.60 (p 0.0086, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.71 (p 8.7e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.67 to -0.50, sign flips 0; without severely affected donors -0.55 (p 0.017, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MINK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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