Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it | 0.72 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 678 | 0.71 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7922
Sealed predictions
- MFGE8 in dopamine neurons, braak-0.05 (p 0.893) → -0.80 (p 0.010)receipt 7930
Swarm cases
receipt 7930: MFGE8 in dopamine neurons, braak
- power
- full sample -0.42 (p 0.086, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.42 (p 0.086, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.035, n 18). not the mix.
- skeptic
- leave-one-out range -0.50 to -0.35, sign flips 0; without severely affected donors -0.42 (p 0.086, n 18). robust.
- cell type
- strongest in astrocytes: -0.73 (p 5.6e-4, n 18) vs -0.42 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MFGE8 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MFGE8 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.20 p 0.477 (needs p < 2.7e-4)
Receipts
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