Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 754 | 0.74 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 11694
Sealed predictions
- MDM4 in dopamine neurons, braak+0.31 (p 0.416) → -0.07 (p 0.852)receipt 11701
Swarm cases
receipt 11701: MDM4 in dopamine neurons, braak
- power
- full sample +0.03 (p 0.915, n 18), 95% CI -0.45 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.14, sign flips 5; without severely affected donors +0.03 (p 0.915, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MDM4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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