Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.21 (overall 0.13) | 0.21 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 1,709 | 0.79 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2272
Sealed predictions
- MCM2 in dopamine neurons, braak-0.36 (p 0.347) → -0.10 (p 0.790)receipt 2279
Swarm cases
receipt 2279: MCM2 in dopamine neurons, braak
- power
- full sample -0.34 (p 0.161, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.161, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.225, n 18). could be the mix.
- skeptic
- leave-one-out range -0.51 to -0.27, sign flips 0; without severely affected donors -0.34 (p 0.161, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MCM2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts