Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

MARCHF5

membrane associated ring-CH-type finger 5

translation score 0.37, read 2026-10-24; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 200.85
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 8708

Sealed predictions

  1. MARCHF5 in dopamine neurons, braakn/a → n/areceipt 8715

Swarm cases

receipt 8715: MARCHF5 in dopamine neurons, braak

cell type
MARCHF5 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MARCHF5 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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