Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 357 | 0.71 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8055
Sealed predictions
- LSP1 in dopamine neurons, braak-0.51 (p 0.163) → -0.29 (p 0.442)receipt 8063
Swarm cases
receipt 8063: LSP1 in dopamine neurons, braak
- power
- full sample -0.48 (p 0.046, n 18), 95% CI -0.77 to -0.01. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.46 (p 0.052, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.61 (p 0.0072, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.41, sign flips 0; without severely affected donors -0.48 (p 0.046, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LSP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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